Semaglutide

Intended Use: Semaglutide is designed for Research Purposes only.

Storage: Store the vial in a cool, dry place away from direct sunlight. Once reconstituted, keep refrigerated at 2-8°C.

Solubility: Reconstitute with bacteriostatic water for best results.

Shelf Life: The lyophilized form has a shelf life of 24 months when properly stored. Once reconstituted, refrigerate and use within 4-6 weeks.

Handling: Ensure sterile techniques are used to maintain the product’s integrity during research.

Study on Weight Loss

Semaglutide leads to significant weight loss.In a study, adults with obesity lost an average of 14.9% of their body weight over 68 weeks with semaglutide, compared to just 2.4% with a placebo. About 86% of participants lost at least 5% of their body weight.

Study on Cardiovascular Health

Semaglutide reduces cardiovascular events.The SELECT trial showed that semaglutide reduced major adverse cardiovascular events by 20% in adults with preexisting cardiovascular disease and obesity. This included fewer heart attacks and strokes compared to those on a placebo.

Study on Long-Term Weight Management

Semaglutide sustains weight loss over four years.In a long-term study, participants maintained a 10.2% reduction in body weight over 208 weeks. This study highlighted the durability of semaglutide's weight loss effects and its safety over an extended period.

Study on Waist Circumference

Semaglutide reduces waist circumference.Participants in a study saw an average reduction of 7.7 cm in waist circumference over 208 weeks. This decrease in waist size is important for reducing the risk of metabolic diseases.

Study on Insulin Resistance

Semaglutide improves insulin resistance.A study found that semaglutide helped improve insulin sensitivity in participants, which is crucial for managing and preventing type 2 diabetes. This improvement was seen alongside significant weight loss.

Study on Quality of Life

Semaglutide enhances quality of life.Participants reported better physical and emotional well-being after losing weight with semaglutide. Improvements were noted in physical functioning and overall health-related quality of life.

Study on Safety and Tolerability

Semaglutide is generally safe and well-tolerated.Most side effects, like nausea and diarrhea, were mild to moderate and subsided over time. The study confirmed that semaglutide is a safe option for long-term weight management.

Study on Weight Loss in Diverse Populations

Semaglutide effective across different groups.The SELECT trial showed that semaglutide led to clinically meaningful weight loss in both men and women, across various races and body sizes. This suggests its broad applicability for weight management.

GLP-1 Receptor Activation

Semaglutide is a glucagon-like peptide-1 receptor agonist (GLP-1RA). It binds to and activates the GLP-1 receptor, which is involved in several metabolic processes. This activation leads to increased insulin secretion from the pancreatic beta cells and decreased glucagon release, helping to lower blood sugar levels.

Appetite Regulation

Semaglutide helps reduce appetite by acting on the brain's appetite centers. It promotes a sense of fullness and reduces hunger, which leads to lower food intake and supports weight loss.

Slowing Gastric Emptying

Semaglutide slows down the emptying of the stomach, which prolongs the digestion process. This results in a feeling of fullness for a longer period, reducing the urge to eat frequently and helping with weight management.

Enhancing Insulin Secretion

By mimicking the incretin hormone GLP-1, semaglutide enhances the body's insulin response to high blood sugar levels. This helps stabilize blood sugar levels and supports better glycemic control.

Reducing Glucagon Production

Semaglutide decreases the production of glucagon, a hormone that increases blood sugar levels by promoting glycogen breakdown and glucose production in the liver. This reduction helps lower overall blood sugar levels.

Cardiovascular Benefits

Semaglutide has been shown to reduce cardiovascular risk factors, such as lowering blood pressure and improving lipid profiles. This is partly due to its effects on weight loss and blood sugar control, which reduce strain on the heart.

Energy Expenditure and Lipid Metabolism

Semaglutide influences energy expenditure and lipid metabolism by activating pathways that increase insulin secretion and promote the breakdown of fats. This helps in reducing body weight and improving metabolic health.