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  • Enhances Weight Loss
  • Improves Glycemic Control
  • Cardiovascular Risk Reduction

Semaglutide is a GLP-1 receptor agonist known for its significant impact on weight loss, glycemic control, and cardiovascular risk reduction. It is widely used in the treatment of type 2 diabetes and obesity, helping patients manage these conditions more effectively and improve overall health.

Legal Notice: This item is available exclusively for scientific research purposes. It is sold in a lyophilized (freeze-dried) state, contained within a hermetically sealed and sterile vial. Use requires extra equipment such as bacteriostatic water for reconstitution, syringes and needles for extraction, and alcohol swabs to sanitize vial caps. The cap color, may differ from the images shown.

Benefits and Applications

  • Significant Weight Loss: Semaglutide has shown remarkable efficacy in promoting weight loss, with clinical trials demonstrating greater weight reduction compared to placebo and other weight loss interventions. It works by reducing appetite, increasing feelings of fullness, and slowing gastric emptying, leading to sustained weight loss.
  • Improves Glycemic Control: Semaglutide helps improve glycemic control by increasing insulin secretion, reducing glucagon secretion, and enhancing glucose uptake in peripheral tissues. It lowers fasting and postprandial glucose levels, improves HbA1c levels, and reduces the risk of hypoglycemia in individuals with type 2 diabetes.
  • Cardiovascular Benefits: Semaglutide has shown cardiovascular benefits beyond glycemic control, including reductions in the risk of major adverse cardiovascular events (MACE) such as heart attack, stroke, and cardiovascular death. It helps improve vascular function, reduce inflammation, and lower blood pressure, leading to improved cardiovascular outcomes.
  • Supports Long-Term Weight Maintenance: Semaglutide's effects on appetite suppression and metabolic regulation may help individuals maintain weight loss over the long term. It promotes healthier eating habits, reduces cravings for high-calorie foods, and prevents weight regain after initial loss.
  • Potential for Non-Diabetic Conditions: Semaglutide may have potential applications beyond type 2 diabetes, including obesity, non-alcoholic fatty liver disease (NAFLD), and chronic kidney disease (CKD). It shows promise in improving metabolic health and reducing the risk of related complications in these conditions.

Research and Studies

Study Title: "Efficacy of Semaglutide in Glycemic Control for Type 2 Diabetes Patients"

  • Method: This randomized, controlled trial evaluated the effects of semaglutide on glycemic control in patients with type 2 diabetes. Participants were administered varying doses of semaglutide once weekly.
  • Results: Semaglutide significantly improved HbA1c levels, with reductions up to 1.5% compared to baseline over a 26-week period.
  • Conclusion: Semaglutide is highly effective in improving glycemic control in type 2 diabetes patients, supporting its use as a leading therapeutic option in diabetes management.

Study Title: "Impact of Semaglutide on Cardiovascular Outcomes in Type 2 Diabetes"

  • Method: In this large-scale cardiovascular outcomes trial, semaglutide was tested for its effects on major adverse cardiovascular events (MACE) in type 2 diabetes patients at high risk of cardiovascular disease.
  • Results: Treatment with semaglutide led to a significant reduction in the risk of MACE, including heart attack, stroke, and cardiovascular death, by approximately 26%.
  • Conclusion: Semaglutide not only manages blood glucose but also reduces the risk of cardiovascular events, enhancing its profile as a cardioprotective diabetes medication.

Study Title: "Semaglutide as a Treatment for Obesity"

  • Method: A multicenter study assessed the effectiveness of semaglutide in promoting weight loss among obese and overweight individuals without diabetes.
  • Results: Participants receiving semaglutide experienced an average weight loss of up to 15% of their body weight over 68 weeks, which was significantly greater than the control group.
  • Conclusion: Semaglutide is effective in substantial weight reduction, making it a promising treatment option for obesity management.

Study Title: "Comparative Effectiveness of Semaglutide Versus Other GLP-1 RAs"

  • Method: This comparative study evaluated semaglutide against other GLP-1 receptor agonists in terms of efficacy, safety, and patient outcomes in diabetes treatment.
  • Results: Semaglutide consistently showed superior outcomes in lowering blood glucose and weight loss when compared to other GLP-1 receptor agonists.
  • Conclusion: Semaglutide offers advantages over other GLP-1 RAs in terms of efficacy and patient satisfaction, reinforcing its position as a preferred treatment option in its class.

These studies highlight the effectiveness of semaglutide in managing type 2 diabetes, reducing cardiovascular risks, and aiding in significant weight loss. Its broad therapeutic benefits and strong safety profile underscore its importance in contemporary therapeutic strategies for diabetes and obesity.

Mechanism of Action

Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist used primarily for the treatment of type 2 diabetes and, more recently, for obesity. Its effectiveness stems from its ability to mimic the functions of the natural incretin hormone GLP-1, which is involved in regulating blood sugar and appetite.

Enhancement of Insulin Secretion

The primary mechanism by which semaglutide operates is the stimulation of insulin secretion from the pancreas. By binding to the GLP-1 receptors on pancreatic beta cells, semaglutide enhances the release of insulin in response to elevated blood glucose levels. This action helps lower blood sugar levels and stabilizes them, reducing the risk of the high peaks and low troughs associated with diabetes.

Suppression of Glucagon Release

In addition to promoting insulin secretion, semaglutide suppresses the release of glucagon from pancreatic alpha cells. Since glucagon normally signals the liver to release stored glucose, its inhibition by semaglutide leads to a reduction in hepatic glucose output, further aiding in blood glucose control.

Delay in Gastric Emptying

Semaglutide slows gastric emptying, which means it takes longer for the stomach to empty its contents into the intestine. This delay helps moderate the rise in blood sugar following meals, provides a longer sensation of fullness, and reduces appetite, contributing to lower overall caloric intake.

Appetite Suppression and Weight Loss

One of the significant benefits of semaglutide, especially in the context of obesity treatment, is its ability to reduce appetite. Through its action on GLP-1 receptors in the brain, it influences satiety and hunger signals, leading to decreased food intake. This effect, combined with enhanced feelings of fullness due to slower gastric emptying, contributes significantly to weight loss.

Cardiovascular Benefits

Semaglutide has also shown benefits in cardiovascular health for people with type 2 diabetes, who are at increased risk of heart disease. Clinical studies have indicated that semaglutide can reduce the risk of major adverse cardiovascular events, including heart attack, stroke, and cardiovascular death.

Impact on Lipid Metabolism

Beyond its effects on glucose metabolism, semaglutide has a positive impact on lipid profiles. It can help lower levels of LDL cholesterol and triglycerides while increasing HDL cholesterol, further enhancing its cardiovascular protective effects.

Therapeutic Applications

Semaglutide is administered via injection and more recently as an oral formulation, making it a versatile and effective option for managing type 2 diabetes and assisting with weight loss in obese or overweight patients. Its broad range of actions makes it a cornerstone drug in modern diabetes care and obesity management.

Safety and Side Effects

Side Effects:
The use of semaglutide can lead to a range of side effects, which are important to consider. These include:

  • Gastrointestinal issues: Nausea, vomiting, diarrhea, abdominal pain, and constipation are common. These side effects are often most pronounced when treatment is initiated and can diminish over time.
  • Risk of pancreatitis: There is a noted increased risk of pancreatitis in patients using GLP-1 receptor agonists like semaglutide.
  • Changes in appetite: Semaglutide often results in reduced appetite, which can be beneficial for weight loss but might also lead to nutritional deficiencies if not monitored.
  • Hypoglycemia: Particularly when used in combination with other diabetes medications like sulfonylureas or insulin, semaglutide can increase the risk of low blood sugar episodes.
  • Thyroid tumors: In animal studies, semaglutide has been linked to a risk of thyroid C-cell tumors, but it is unclear if this risk is relevant to humans.

Safety Profile:

  • FDA approval: Semaglutide is approved by the FDA for the treatment of type 2 diabetes and as a treatment option for chronic weight management in adults with obesity or overweight status who have at least one weight-related condition (such as hypertension, type 2 diabetes, or dyslipidemia).
  • Administration: It is administered through injections, typically once a week, making it a convenient option for many patients.
  • Long-term use: Studies on long-term use show that semaglutide effectively manages blood sugar levels and aids in sustained weight loss, but it is essential to continue monitoring for potential long-term adverse effects.


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