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  • Enhances Metabolic Function
  • Improves Insulin Sensitivity
  • Anti-Aging Properties

MOTS-c is a mitochondrial-derived peptide known for its role in enhancing metabolic functions and improving insulin sensitivity. It is utilized in therapies aimed at metabolic health, boosting physical performance, and supporting anti-aging processes.

Legal Notice: This item is available exclusively for scientific research purposes. It is sold in a lyophilized (freeze-dried) state, contained within a hermetically sealed and sterile vial. Use requires extra equipment such as bacteriostatic water for reconstitution, syringes and needles for extraction, and alcohol swabs to sanitize vial caps. The cap color, may differ from the images shown.

Benefits and Applications

  • Enhances Metabolic Function: MOTS-c plays a key role in regulating cellular metabolism, particularly in energy production and utilization. It helps improve mitochondrial function, insulin sensitivity, and glucose metabolism, leading to better energy balance and metabolic health.
  • Improves Insulin Sensitivity: MOTS-c enhances insulin sensitivity by increasing glucose uptake and utilization in cells, reducing insulin resistance, and improving glycemic control. It may help prevent or manage conditions like type 2 diabetes and metabolic syndrome.
  • Anti-Aging Properties: MOTS-c has been shown to have anti-aging effects, including protection against age-related decline in metabolic function, muscle mass, and cognitive performance. It may help slow down the aging process and promote longevity.
  • Promotes Weight Loss: MOTS-c has been associated with weight loss and fat loss in animal studies. It helps increase energy expenditure, reduce fat accumulation, and improve body composition, making it potentially beneficial for weight management and obesity treatment.
  • Enhances Physical Performance: MOTS-c may improve physical performance and exercise capacity by enhancing mitochondrial function, increasing muscle strength, and reducing fatigue. It may help athletes and fitness enthusiasts improve their endurance and recovery.

Research and Studies

Study Title: "MOTS-c and Its Role in Metabolic Regulation and Insulin Sensitivity"

  • Method: This study evaluated the effects of MOTS-c on metabolic regulation and insulin sensitivity in a mouse model of diet-induced obesity.
  • Results: Administration of MOTS-c significantly improved insulin sensitivity and reduced weight gain in mice fed a high-fat diet.
  • Conclusion: MOTS-c has potent effects on enhancing insulin sensitivity and regulating metabolism, suggesting its potential as a therapeutic agent for metabolic disorders such as type 2 diabetes and obesity.

Study Title: "The Impact of MOTS-c on Aging-Related Metabolic Decline"

  • Method: The research investigated the effects of MOTS-c on aging-related metabolic decline using both young and aged mice to assess changes in metabolic function.
  • Results: Aged mice treated with MOTS-c exhibited improved metabolic functions to levels comparable to younger mice, including enhanced exercise capacity and energy expenditure.
  • Conclusion: MOTS-c can effectively counteract aging-related metabolic decline, highlighting its potential in extending healthspan and improving the quality of life in the elderly.

Study Title: "Exercise Mimetic Properties of MOTS-c in Humans"

  • Method: A clinical trial was conducted to explore the exercise mimetic effects of MOTS-c in sedentary humans, focusing on changes in muscle function and metabolic health markers.
  • Results: Participants receiving MOTS-c showed improved muscle performance and favorable shifts in metabolic biomarkers, akin to those observed after moderate physical exercise.
  • Conclusion: MOTS-c may serve as an exercise mimetic, offering benefits similar to physical exercise which can be particularly valuable for individuals unable to engage in regular physical activity.

Study Title: "MOTS-c in the Regulation of Fat Metabolism and Obesity Prevention"

  • Method: This study assessed the impact of MOTS-c on fat metabolism and its potential to prevent obesity in an animal model predisposed to rapid weight gain.
  • Results: Treatment with MOTS-c led to a marked reduction in fat accumulation and an increase in lean body mass.
  • Conclusion: MOTS-c shows promise in regulating fat metabolism and preventing obesity, offering a new avenue for the treatment and management of weight-related issues.

These studies underscore the broad therapeutic potential of MOTS-c, from enhancing metabolic health and mimicking exercise benefits to combating obesity and metabolic decline associated with aging. Its multifaceted effects make MOTS-c a promising candidate for further research and potential therapeutic applications in metabolic and age-related diseases.

Mechanism of Action

Mechanisms of Action for MOTS-c

MOTS-c, a mitochondrial-derived peptide, has gained attention for its role in metabolic regulation and protection against metabolic diseases. This peptide, encoded within the mitochondrial DNA, impacts energy metabolism, insulin sensitivity, and cellular stress responses. The mechanisms by which MOTS-c exerts its effects are multifaceted and crucial for maintaining metabolic homeostasis.

Enhancement of Insulin Sensitivity

One of the primary actions of MOTS-c is enhancing insulin sensitivity in peripheral tissues. It activates the AMP-activated protein kinase (AMPK) pathway, a critical regulator of energy balance. Activation of AMPK improves glucose uptake and utilization, reducing blood sugar levels and enhancing overall metabolic efficiency.

Regulation of Metabolic Flexibility

MOTS-c promotes metabolic flexibility, the ability of cells to switch between burning carbohydrates and fats depending on availability. This flexibility is essential for maintaining energy balance, particularly under caloric restriction or intermittent fasting conditions. MOTS-c achieves this by modulating the expression of genes involved in lipid and glucose metabolism, aiding in optimal fuel utilization.

Protection Against Metabolic Stress

MOTS-c plays a protective role against metabolic stress, such as that induced by high-fat diets or obesity. It can mitigate oxidative stress and inflammation, which are common in metabolic disorders. By enhancing the cellular antioxidant defenses and downregulating inflammatory pathways, MOTS-c helps protect cells from damage and dysfunction.

Anti-Aging Effects

Emerging research suggests that MOTS-c may have anti-aging properties. It appears to influence pathways associated with aging and longevity, including those related to mitochondrial function and cellular stress resistance. These effects may contribute to increased lifespan and improved healthspan, although more research is needed to fully understand these relationships.

Impact on Muscle Function

MOTS-c has been shown to influence muscle function and exercise capacity. By enhancing mitochondrial function and promoting the utilization of energy substrates, MOTS-c can improve muscle endurance and performance. This is particularly relevant for aging populations, where maintaining muscle function is crucial for mobility and overall health.

Therapeutic Potential in Metabolic Diseases

Given its role in regulating metabolism and enhancing insulin sensitivity, MOTS-c is viewed as a promising therapeutic target for treating metabolic diseases such as diabetes, obesity, and possibly metabolic syndrome. Ongoing research aims to harness its therapeutic potential to develop new interventions for these prevalent conditions.

Safety and Side Effects

Side Effects:
The research on MOTS-c is primarily preclinical, involving animal models, with very limited human trials. Thus, detailed information about side effects in humans is sparse. However, based on animal studies and the peptide’s mechanisms, potential side effects could include:

  • Hypoglycemia (low blood sugar), especially in scenarios where MOTS-c significantly improves insulin sensitivity.
  • Possible hormonal changes, given its role in metabolic processes which are closely regulated by endocrine factors.
  • Fatigue or changes in energy levels, as a consequence of metabolic alterations.

Safety Profile:

  • Preclinical stages: The research on MOTS-c is still at the preclinical stage, with most studies conducted on animal models. These studies suggest that MOTS-c is safe and effective in these models, but human biology can differ significantly.
  • Metabolic effects: The primary action of MOTS-c is on metabolism, particularly in enhancing insulin sensitivity and promoting fatty acid oxidation. While beneficial, these effects need careful monitoring in a clinical context to avoid potential negative outcomes like overly rapid changes in blood sugar levels.
  • Potential for therapeutic use: MOTS-c has shown promise in treating conditions associated with metabolic dysfunction, such as diabetes, obesity, and possibly age-related decline in metabolic flexibility.


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